Using the ribosome to synthesize peptidomimetics
نویسندگان
چکیده
منابع مشابه
Using the ribosome to synthesize peptidomimetics
Peptidomimetic research is an approach to identify peptide-based drugs designed to mimic structural, conformational, and biological properties of peptides while overcoming their limitations, such as protease instability and poor cell penetration. With recent advances in ribosomal synthesis of peptides containing unnatural amino acids, this technology appears suitable for preparing large structu...
متن کاملA peptide ligase and the ribosome cooperate to synthesize the peptide pheganomycin.
Peptide antibiotics are typically biosynthesized by one of two distinct machineries in a ribosome-dependent or ribosome-independent manner. Pheganomycin (PGM (1)) and related analogs consist of the nonproteinogenic amino acid (S)-2-(3,5-dihydroxy-4-hydroxymethyl)phenyl-2-guanidinoacetic acid (2) and a proteinogenic core peptide, making their origin uncertain. We report the identification of the...
متن کاملUsing SyGuS to Synthesize Reactive Motion Plans
We present an approach for synthesizing reactive robot motion plans, based on compilation to SyntaxGuided Synthesis (SyGuS) specifications. Our method reduces the motion planning problem to the problem of synthesizing a function that can choose the next robot action in response to the current state of the system. This technique offers reactivity not by generating new motion plans throughout dep...
متن کاملUsing Motion Capture to Synthesize Dance Movements
Motion capture presents an interesting opportunity for the analysis and synthesis of movements in dance. We describe a tool that uses concatenative synthesis of dance movement based on a library of prerecorded basic movements. Dance movements are first broken into discrete, small movements following the guidelines of Laban dance notation. Then these movements can be performed by dancers and rec...
متن کاملUsing Laccases in the Nanoflower to Synthesize Viniferin
The pH stability of the free laccase and the immobilized laccase was determined by incubating the enzyme in different buffers (pH 3.0-8.0) for 6 h at 35 °C. The buffers used were Na2HPO4–sodium citrate buffer (pH 3.0-8.0). The immobilized laccase was collected by centrifugation (3500 g for 3 min) and air-dried. The residual specific activities of free or immobilized laccase were then determined...
متن کاملذخیره در منابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
ژورنال
عنوان ژورنال: F1000 Biology Reports
سال: 2009
ISSN: 1757-594X
DOI: 10.3410/b1-53